Science and evidence

Evidence model

The refusals are part of the product, not gaps in it. When Livemore Bio cannot answer from admitted evidence, it names the missing measurement instead of producing a plausible-looking number.

Result fields

Field What it tells you
evidence_state What kind of result it is, for example MODELED_ONLY, MODELED_MECHANISTIC or MODELED_STEADY_STATE
qualification_state Whether it has been qualified against independent measurements. Nothing is qualified today: results are NOT_QUALIFIED, and research comparisons wait at REVIEW_REQUIRED
applicability · interpretation_limits Where the protocol defines them: the physiology and context the model covers, and what it does not cover
controls Checks that run on every execution: zero-dose equals untreated, mass balance, conservation
claims_allowed · claims_prohibited Where the protocol defines them: which statements the result can and cannot support
calibration_authorized Always false until an independent evidence review authorizes calibration. No model calibrates itself
provenance Input and source SHA-256 digests, the pinned model commit, the solver and its version, and the citation behind each parameter

Validation levels

Every claim states its validation level.

  • A visual demonstration is not scientific validation.
  • A simulation is not clinical validation.
  • A wet-lab signal is not human efficacy.

Telemetry from the LIFE Patch updates observed state only and never silently recalibrates a model. Calibration stays unauthorized until an independent evidence review allows it: no model calibrates itself.

Not built yet

  • The physical LIFE Patch. The B0 EVT design target has known electrical release blockers.
  • The Cendos wet lab.
  • Person-calibrated or context-validated models.
  • Production PHI handling.

How to evaluate Livemore Bio

  • Try to make it lie. Ask for a dose nobody measured, a compound with no pharmacokinetic source, or a twin with no admitted model. Each should refuse with a reason code and name the missing measurement.
  • Read the controls block. A zero-dose arm must reproduce the untreated arm exactly, and conservation identities must hold. These run on every execution, not on request.
  • Read evidence_state and qualification_state. Every result is a modeled state, and nothing is qualified. Nothing here claims to be validated.
  • Check the provenance. Every number carries its pinned sources, solver and citations.

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