Livemore
Livemore Bio 0.1.0: fidelity advisoryRead before use

A living, biological replica of every human

We are building a replica of each person’s biology: living tissues, organs and cells that respond to a medicine the way that person’s own would. We use it to find better medicines for chronic disease, starting with medicines from plants.

See how it works Read the docs

AegleAtlas

The Aegle Atlas page: a whole-body reference anatomy beside the multiscale path from body to organ, tissue, cell, ion channel and gene
Aegle Atlas, from the whole person down to a single gene.

The problem

Why chronic disease resists today’s medicine

  • Disease treated as one number

    Chronic disease is an ecosystem of interacting pathways, yet treatment usually targets a single marker.

  • Medicine built for the average

    Trials and doses are designed for populations, so the same drug helps one person and fails the next.

  • Plant medicine left unproven

    Remedies used for generations, including in African traditional medicine, are rarely standardised or tested.

  • Preclinical models miss people

    Most candidates that enter human trials fail, often because earlier models did not reflect human biology.

How it works

Start with a question. Test it on the person.

Phytomedicine and preclinical research feed one replica of the person. Every candidate is tested against that person’s biology before it moves forward.

  1. Question

    Does cyanidin-3-glucoside from bilberry reach its active range at 500 mg?

    • Bilberry
    • Cyanidin-3-glucoside
    • 500 mg

    Ask one clear question

    Each program answers a narrow question, set before anything runs.

  2. Aegle · the twin

    Research person A

    • Glucose–insulin regulationRuns
    • Ventricular electrophysiologyRuns
    • Parameters and their sourcesOwn

    Put it to one person’s twin

    Each twin keeps its own parameters and their sources, so one person’s twin is not another’s.

  3. Cendos · the lab

    Bilberry exposure protocol

    • Model the exposureDone
    • Compare with the measured active rangeDone
    • Run the controlsDone
    • Record the runDone

    The lab runs it

    Cendos runs the protocol with controls on every run, and records it so anyone can reopen it and run it again.

  4. Answer

    1.41

    Margin at 500 mg

    The modeled peak reaches the measured active range.

    • Evidence attached
    • Sources pinned
    • CSV
    • Notebook

    Get an answer with its evidence

    Every result carries its evidence, its controls and its sources, and exports as a spreadsheet or an executable notebook.

First programs

  • Insulin
  • Greater burdock · arctigenin
  • Bilberry · cyanidin-3-glucoside
  • Lion’s mane · erinacine A
  • Yerba santa · sterubin
  • Rosemary · carnosic acid
Read about the programs

The platform

Three systems. One person.

Aegle, LIFE and Cendos share one twin, so a model, a measurement and an experiment all describe the same human being.

  • AegleTwins

    The Aegle Twins page, creating a digital twin and listing the available twins

    Aegle

    The digital twin

    One individualized twin per person, from molecules up to whole-body regulation.

  • LIFELIFE Patch

    The LIFE Patch page, binding a patch to a twin and streaming biomarkers

    LIFE

    Measurement from the person

    Built around the LIFE Patch, a skin-worn sensing device. The patch belongs to the person, and its virtual counterpart to their twin.

  • CendosCendos Lab

    The Cendos Lab page, showing a recorded protocol run with paired control and treated arms

    Cendos

    The lab

    Where predictions meet measurement. Cendos runs protocols on the twin and on genome-scale human metabolism.

In your browser

Everything happens in pages

Livemore Bio runs on your own machine and opens in your browser. Every page works on the same twin.

AegleBiology

The Biology page, inspecting one person's response at organ, cell and molecular level

  • Atlas

    The whole person, from body to organ, tissue, cell, ion channel and gene.

  • Twins

    Create, admit and activate a person’s twin.

  • Cohorts

    Build reproducible groups and freeze them.

  • Cendos Lab

    Prepare, run, reopen and re-run experiments.

  • Biology

    See a response at organ, cell and molecular level.

  • LIFE Patch

    Bind a patch to a twin and follow the biomarker stream.

  • Research

    Freeze a prediction, admit a measurement and compare them.

  • Knowledge

    The scientific sources behind every model.

Roadmap

Built so far, and what comes next

Built so far

  • Livemore Bio 0.1.0, released
  • Mechanistic models of metabolism and the heart
  • A whole-human reference framework
  • First natural-product research programs

  1. Next release · Livemore Bio 0.2.0

    Experiments in plain English

    A browser app to set up and run experiments in plain English, with no terminal.

  2. The first physical lab experiment

    One falsifiable Cendos assay, compared against a held-out measurement.

  3. The LIFE Patch, on the bench and on people

    Hardware verified, then consented measurements paired with reference instruments.

  4. More of the body, made executable

    Cardio-metabolic first, then renal, hepatic, endocrine and beyond.

  5. Treatment-free resilience

    Measurable protocols for health that holds after treatment stops.

  6. Ready for pharmaceutical partners

    Security, reviewer sign-off and a regulatory review for each intended use.

Our values

How we work

  • No fakes, ever

    Nothing is invented to make a result look better.

  • Measurement decides

    When data and model disagree, the data wins.

  • Evidence on every claim

    Each result says how far it has been proven.

  • Consent and provenance

    Every data point traces to its source, and a real person’s data to their consent.

Partner with us

Build the evidence with us

We are looking for pharmaceutical, laboratory and clinical partners.

Partner with us