Capabilities

What each part of Livemore Bio does in release stable 6588707. For what is not built yet, see the evidence model and the roadmap.

Individualized twins and cohorts

Admit a consented real-human profile with field-level EHR, laboratory, device, medication, genomic, lifestyle and environmental provenance. Missing domains stay missing.
Or create a non-person research twin on the server from a pinned public-population manifest (NHANES 2021–2023 and published Diabetes Prevention Program baseline anchors).
Frozen cohorts record their synthetic member profiles, seeds, source lineage and fingerprints. Synthetic and real-human members are never mixed.
Exactly one twin is authoritative across Atlas, LIFE Patch, Cendos, the terminal and notebooks.

Glucose–insulin dynamics: reduced Bergman ODEs solved with SciPy/LSODA.
Exogenous insulin: the published Hovorka model, with source lineage for every parameter.
Ventricular electrophysiology: O'Hara–Rudy CiPA 2017 (49 states), run natively through Myokit/CVODE from CellML. It models the hERG/IKr block to APD prolongation mechanism.
Cross-scale coupling rules between metabolic and cardiac state. Their magnitude has no admitted source yet, and they are labelled as hypotheses.

Six reference programs: exogenous insulin plus five botanical compounds. See reference programs.
Human-GEM 2.0 constraint-based metabolism in an isolated COBRApy/GLPK worker, with GPR-aware gene knockouts and negative controls.
Protocols for metformin across two cohorts, garcinoic acid and human PXR, and a lobeline/VMAT2 initial-rate assay.
Every run made through the services is immutable. It can be reopened, re-run with a parent link, and exported as CSV and an executable Jupyter notebook.

LIFE Patch v2 contract: manifest, telemetry, quality, commands and receipts, shared by the physical and virtual device.
The virtual LIFE Patch binds to a twin and streams modeled channels. Unmodeled channels show UNAVAILABLE.
Admission rejects invalid or replayed data and writes an encrypted journal. Telemetry updates observed state only and never silently recalibrates the model.
The B0 hardware target (MAX30003 ECG, MAX86141 optical, AD5940 electrochemistry, DS28C36 pod authentication) is specified, not manufactured.

evidence_state and qualification_state on every result, plus applicability and interpretation_limits where the protocol defines them.
claims_allowed and claims_prohibited state what a result can and cannot support.
Controls run on every execution. For example, a zero-dose arm must reproduce the untreated arm exactly.
Pinned model commits and SHA-256 digests, solver versions, and literature lineage for each parameter.

See the evidence model for every field.

A whole-human manifest with an eight-step maturity ladder for each body system. See whole-human coverage.
A scientific-source catalog of 2,647 entries: all 39 ELIXIR Core Data Resources, 2,594 NAR database summaries and 14 Livemore adapters. Each entry moves through a lifecycle from cataloged to scientifically_qualified. Catalog entries are never queried by experiments until they are wired and qualified.
Adapter readiness, license links and credential gates. Commercially restricted sources (for example KEGG, GeneCards, Recon3D) fail closed without entitlement.
A knowledge graph (Gene, Disease, Pathway, Organ and Drug) and a TF-IDF retrieval index.